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Michael J. Clare-Salzler, MD

Clare SalzlerMichael J. Clare-Salzler, MD
Professor and Chairman
Director, Center for Immunology & Transplantation

TEL: (352) 273-7839
FAX: (352) 273-8172

 

 

Dr. Clare-Salzler received his Doctor of Medicine and medical training from the State University of New York in Buffalo.  He began his research career at the University of California in Los Angeles, where he studied the immunopathogenesis of Type I diabetes (T1D) in NOD mice, which is the genetic mouse model for T1D.  Since transferring to the University of Florida Department of Immunology, Pathology and Laboratory Medicine and Internal Medicine and Surgery in 1993, Dr. Clare-Salzler has been pursuing his research in T1D diagnosis and management, autoimmune thyroid disease, and other endocrine diseases.  He participates in many clinical trials, including the PANDA infant screening program and the Diabetes Prevention Trial for T1D.

Degree/Program

Institution

Field/Specialty

BS

University of Notre Dame

Pre-Professional Studies

MD

SUNY at Buffalo

Medicine

Residency

SUNY at Buffalo Affiliated Hospitals

Internal Medicine

Fellowship

University of California

Adult Endocrinology and Diabetes

Academic/Research Interests:

Dr. Clare-Salzler’s research focus is to establish the cellular, molecular, and genetic basis for the immunpathogenesis of Juvenile or Type I diabetes and other autoimmune endocrine diseases.  He and his team have concentrated their efforts on the role of antigens such as glutamate decarboxylase (GAD) and the biology of antigen presenting cells as it relates to the generation of protective and pathogenic immune responses in an animal model of Type I diabetes, the non-obese diabetic mouse (NOD) as well as in humans with an established high risk for this disease.

Recent work has lead to the identification of a number of  immunophenotypes in NOD mice and human subjects with a high risk for Type I diabetes. These immunophenotypes involve the regulation of prostaglandin metabolism in macrophages/monocytes and dysregulation of pathways involved in activation induced cell death in lymphocytes. Utilizing congenic mice we have identified chromosomal intervals that contribute to these phenotypes. They are currently evaluating candidate genes in these intervals and are also determining the role of TNF in the development of organ dysfunction, particularly liver injury, in a murine model of sepsis and inflammation. The team has defined that NOD mice are highly resistant to this form of liver injury in comparison to other standard strains of mice. They are currently dissecting the genetic contributions to this resistance using a congenic mouse approach.

Clinical Interests:

Dr. Clare-Salzler‘s areas of clinical expertise lie in the diagnosis and management of Type I diabetes, autoimmune thyroid disease, management of thyroid nodules, fine needle aspiration of thyroid nodules and thyroid cancer. He is also well versed in other endocrine diseases including Cushing’s Disease, pituitary disease, pheochromocytoma, adrenal tumors and parathyroid diseases.

Dr. Clare-Salzler is also a member of the NIH funded International Multi-Center diabetes prevention trial, the Diabetes Prevention Trial for Type I diabetes or DPT-1. He is also an investigator on other diabetes screening programs at the University of Florida including the infant screening program PANDA.

 Please click here for a list of Dr. Clare-Salzler’s industry relationships.