Hans K Ghayee

Hans K Ghayee, DO

Associate Professor; VA Section Chief

Department: MD-ENDOCRINOLOGY
Business Phone: (352) 273-8656

About Hans K Ghayee

Dr. Hans Ghayee received his osteopathic medical degree from the University of North Texas Health Science Center at Fort Worth. He did his Internal Medicine Residency at Johns Hopkins University/Sinai Hospital, followed by a fellowship, focusing on metabolism and steroidogenesis at University of Texas Southwestern Medical Center.

Teaching Profile

Courses Taught
2020-2023
PAS5010 Intro to Medicine 1

Board Certifications

  • Endocrinology, Diabetes and Metabolism
    American Board of Internal Medicine

Clinical Profile

Specialties
  • Endocrinology, Diabetes and Metabolism
Areas of Interest
  • Adrenal glands
  • Pheochromocytoma

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-9201-3033

Publications

2024
Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners.
Nature communications. 15(1) [DOI] 10.1038/s41467-023-44563-7. [PMID] 38212624.
2024
Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement.
Nature reviews. Endocrinology. 20(3):168-184 [DOI] 10.1038/s41574-023-00926-0. [PMID] 38097671.
2024
Niche for polyamine inhibition in treatment of metastatic pheochromocytoma and paraganglioma
European Journal of Clinical Investigation. 54(5) [DOI] 10.1111/eci.14162.
2024
Some patients with type 2 diabetes may benefit from intensive glycaemic and blood pressure control: A post-hoc machine learning analysis of ACCORD trial data.
Diabetes, obesity & metabolism. 26(4):1502-1509 [DOI] 10.1111/dom.15453. [PMID] 38297986.
2023
Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
The lancet. Diabetes & endocrinology. 11(5):345-361 [DOI] 10.1016/S2213-8587(23)00038-4. [PMID] 37011647.
2023
Internal Carotid Artery Aneurysm Disguised as Pituitary Macroadenoma.
JCEM case reports. 1(4) [DOI] 10.1210/jcemcr/luad076. [PMID] 37908996.
2023
Metabolic Characterization and Glyceraldehyde-3-Phosphate Dehydrogenase-Dependent Regulation of Epithelial Sodium Channels in hPheo1 Wild-type andSDHBKnockdown Cells
Endocrinology. 164(4) [DOI] 10.1210/endocr/bqad026.
2023
Metabolomics in paraganglioma: applications and perspectives from genetics to therapy.
Endocrine-related cancer. 30(6) [DOI] 10.1530/ERC-22-0376. [PMID] 36897220.
2022
Case report: Two sisters with a germline CHEK2 variant and distinct endocrine neoplasias.
Frontiers in endocrinology. 13 [DOI] 10.3389/fendo.2022.1024108. [PMID] 36440216.
2022
Development of Human Adrenocortical Adenoma (HAA1) Cell Line from Zona Reticularis.
International journal of molecular sciences. 24(1) [DOI] 10.3390/ijms24010584. [PMID] 36614027.
2022
Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer.
Cell reports. 40(7) [DOI] 10.1016/j.celrep.2022.111218. [PMID] 35977518.
2022
Germline SUCLG2 Variants in Patients With Pheochromocytoma and Paraganglioma
JNCI: Journal of the National Cancer Institute. 114(1):130-138 [DOI] 10.1093/jnci/djab158. [PMID] 34415331.
2021
Real-World Experience With Automated Insulin Pump Technology in Veterans With Type 1 Diabetes.
Federal practitioner : for the health care professionals of the VA, DoD, and PHS. 38(Suppl 4):S4-S8 [DOI] 10.12788/fp.0156. [PMID] 35136338.
2021
Subacute Thyroiditis and Heart Failure in a Patient Presenting With COVID-19.
Journal of investigative medicine high impact case reports. 9 [DOI] 10.1177/23247096211009412. [PMID] 33853424.
2021
Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas.
Frontiers in endocrinology. 12 [DOI] 10.3389/fendo.2021.589451. [PMID] 33776908.
2021
Vanishing Adrenal Mass in Pregnancy.
AACE clinical case reports. 7(1):72-74 [DOI] 10.1016/j.aace.2020.11.020. [PMID] 33851025.
2020
Activation of RAS Signalling is Associated with Altered Cell Adhesion in Phaeochromocytoma.
International journal of molecular sciences. 21(21) [DOI] 10.3390/ijms21218072. [PMID] 33138083.
2020
Expression of Key Androgen-Activating Enzymes in Ovarian Steroid Cell Tumor, Not Otherwise Specified.
Journal of investigative medicine high impact case reports. 8 [DOI] 10.1177/2324709620933416. [PMID] 32590918.
2020
HIF2α supports pro-metastatic behavior in pheochromocytomas/paragangliomas.
Endocrine-related cancer. 27(11):625-640 [DOI] 10.1530/ERC-20-0205. [PMID] 33112842.
2020
Phosphoprotein-based biomarkers as predictors for cancer therapy
Proceedings of the National Academy of Sciences. 117(31):18401-18411 [DOI] 10.1073/pnas.2010103117. [PMID] 32690709.
2020
Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma.
Cancers. 12(2) [DOI] 10.3390/cancers12020280. [PMID] 31979226.
2020
Targeting pheochromocytoma/paraganglioma with polyamine inhibitors.
Metabolism: clinical and experimental. 110 [DOI] 10.1016/j.metabol.2020.154297. [PMID] 32562798.
2020
Therapeutic Targeting of SDHB-Mutated Pheochromocytoma/Paraganglioma with Pharmacologic Ascorbic Acid.
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(14):3868-3880 [DOI] 10.1158/1078-0432.CCR-19-2335. [PMID] 32152203.
2019
Molecular Mechanisms of Primary Aldosteronism
Endocrinology and Metabolism. 34(4) [DOI] 10.3803/enm.2019.34.4.355.
2019
Pheochromocytomas and Paragangliomas.
Endocrinology and metabolism clinics of North America. 48(4):727-750 [DOI] 10.1016/j.ecl.2019.08.006. [PMID] 31655773.
2019
Pitfalls in the interpretation of the cosyntropin stimulation test for the diagnosis of adrenal insufficiency.
Current opinion in endocrinology, diabetes, and obesity. 26(3):139-145 [DOI] 10.1097/MED.0000000000000473. [PMID] 30855285.
2019
THE EVALUATION OF INCIDENTALLY DISCOVERED ADRENAL MASSES.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 25(2):178-192 [DOI] 10.4158/DSCR-2018-0565. [PMID] 30817193.
2019
The Significant Reduction or Complete Eradication of Subcutaneous and Metastatic Lesions in a Pheochromocytoma Mouse Model after Immunotherapy Using Mannan-BAM, TLR Ligands, and Anti-CD40.
Cancers. 11(5) [DOI] 10.3390/cancers11050654. [PMID] 31083581.
2019
VISUAL VIGNETTE.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 25(4) [DOI] 10.4158/EP-2018-0387. [PMID] 30289297.
2018
BMI trajectories and risk of overall and grade-specific prostate cancer: An observational cohort study among men seen for prostatic conditions.
Cancer medicine. 7(10):5272-5280 [DOI] 10.1002/cam4.1747. [PMID] 30207080.
2018
Diagnostic Testing for Elevated Cortisol in the Setting of an Adrenal Mass.
JAMA. 320(13):1373-1374 [DOI] 10.1001/jama.2018.13351. [PMID] 30326492.
2018
Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas.
The Journal of clinical endocrinology and metabolism. 103(1):46-55 [DOI] 10.1210/jc.2017-01314. [PMID] 28938490.
2018
First Reported Case of Endoscopic Ultrasound-Guided Core Biopsy Yielding Diagnosis of Primary Adrenal Leiomyosarcoma.
Case reports in gastrointestinal medicine. 2018 [DOI] 10.1155/2018/8196051. [PMID] 30402300.
2018
Pheochromocytoma/Paraganglioma: A Poster Child for Cancer Metabolism.
The Journal of clinical endocrinology and metabolism. 103(5):1779-1789 [DOI] 10.1210/jc.2017-01991. [PMID] 29409060.
2018
Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes.
Translational lung cancer research. 7(1):32-49 [DOI] 10.21037/tlcr.2018.02.02. [PMID] 29535911.
2017
Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma.
Cancer cell. 31(2):181-193 [DOI] 10.1016/j.ccell.2017.01.001. [PMID] 28162975.
2017
Delayed Imaging Presentation of a Symptomatic Insulinoma After Bariatric Surgery.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 21(2):412-414 [DOI] 10.1007/s11605-016-3219-7. [PMID] 27561632.
2017
PRECISION MEDICINE IN ADRENAL DISORDERS: THE NEXT GENERATION.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 23(6):672-679 [DOI] 10.4158/EP161716.RA. [PMID] 28332880.
2017
The Yin and Yang Between Plasma Glucose Levels and Cortisol Replacement Therapy in Schmidt’s Syndrome.
Journal of investigative medicine high impact case reports. 5(3) [DOI] 10.1177/2324709617716203. [PMID] 28748191.
2016
AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2α SIGNALING.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 22(2):190-5 [DOI] 10.4158/EP15889.OR. [PMID] 26492543.
2015
Adrenal insufficiency after stereotactic body radiation therapy for bilateral adrenal metastases.
Practical radiation oncology. 5(3):e177-e181 [DOI] 10.1016/j.prro.2014.08.020. [PMID] 25413390.
2015
Strategic Chemotherapy for Pheochromocytoma?
Endocrinology. 156(11):3880-1 [DOI] 10.1210/en.2015-1802. [PMID] 26474362.
2013
Benign adrenal adenomas secreting excess mineralocorticoids and glucocorticoids.
Endocrinology, diabetes & metabolism case reports. 2013 [DOI] 10.1530/EDM-13-0042. [PMID] 24616772.
2013
Phospho-mTOR is not upregulated in metastatic SDHB paragangliomas.
European journal of clinical investigation. 43(9):970-7 [DOI] 10.1111/eci.12127. [PMID] 23889685.
2013
Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor.
PloS one. 8(6) [DOI] 10.1371/journal.pone.0065624. [PMID] 23785438.
2012
Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells.
The Journal of clinical endocrinology and metabolism. 97(8):E1567-72 [DOI] 10.1210/jc.2011-3132. [PMID] 22628608.
2012
Indexing severity of diabetic foot infection with 99mTc-WBC SPECT/CT hybrid imaging.
Diabetes care. 35(9):1826-31 [DOI] 10.2337/dc11-2425. [PMID] 22723341.
2011
Clinical, biochemical, and molecular characterization of macronodular adrenocortical hyperplasia of the zona reticularis: a new syndrome.
The Journal of clinical endocrinology and metabolism. 96(2):E243-50 [DOI] 10.1210/jc.2010-1222. [PMID] 21084398.
2010
The peroxisome proliferator-activated receptor-gamma agonist rosiglitazone increases bone resorption in women with type 2 diabetes: a randomized, controlled trial.
Calcified tissue international. 86(5):343-9 [DOI] 10.1007/s00223-010-9352-5. [PMID] 20354684.
2009
Mediastinal paragangliomas: association with mutations in the succinate dehydrogenase genes and aggressive behavior.
Endocrine-related cancer. 16(1):291-9 [DOI] 10.1677/ERC-08-0214. [PMID] 19075037.
2008
Clinical implications of androgen synthesis via 5alpha-reduced precursors.
Endocrine development. 13:55-66 [DOI] 10.1159/000134780. [PMID] 18493133.
2008
Dehydroepiandrosterone replacement therapy–panacea, snake oil, or a bit of both?
Nature clinical practice. Endocrinology & metabolism. 4(8):442-3 [DOI] 10.1038/ncpendmet0870. [PMID] 18560399.
2008
Hyperthyroidism-associated coronary vasospasm with myocardial infarction and subsequent euthyroid angina.
Thyroid : official journal of the American Thyroid Association. 18(2):273-6 [DOI] 10.1089/thy.2007.0131. [PMID] 18279027.
2008
The many faces of pheochromocytoma.
Journal of endocrinological investigation. 31(5):450-8 [PMID] 18560264.
2007
Basic concepts and recent developments in human steroid hormone biosynthesis.
Reviews in endocrine & metabolic disorders. 8(4):289-300 [PMID] 17926129.
2005
Dirty nails.
The Journal of clinical endocrinology and metabolism. 90(4) [PMID] 15814775.
1997
Do lymphocytes contain chromosomal lesions that are also stable markers in cancer cells?
International journal of oncology. 11(4):681-4 [PMID] 21528261.

Grants

Jul 2023 ACTIVE
VA IPA-Yiling Xu
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
May 2023 ACTIVE
Preclinical Study of a Combination Therapy for PPGL tumors with HIF2 alpha inhibitor Belzutifan plus Polyamine Analogue Inhibitor DENSPM in a PPGL Xenograft Mouse Model
Role: Principal Investigator
Funding: SDHB PHEO PARA COALITION
Jun 2020 – May 2023
Preclinical evaluation of the efficacy and mechanism of action for an alkylated polyamine analogue diethylnorspermine in treating pheochromocytoma/paraganglioma
Role: Principal Investigator
Funding: NATL INST OF HLTH NCATS
Jul 2019 – Mar 2023
Glucocorticoid Receptor Antagonism in the Treatment of Cushing Syndrome (GRACE): A Phase 3, Double-Blind, Placebo-Controlled, Randomized-Withdrawal Study of the Efficacy and Safety of Relacorilant
Role: Principal Investigator
Funding: ICON CLINICAL RESEARCH INC via CORCEPT THERAPEUTICS
Jun 2019 – May 2020
VA IPA-Yiling Xu
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
May 2019 ACTIVE
SDHB Coalition
Role: Principal Investigator
Funding: SDHB PHEO PARA COALITION
Apr 2017 – Mar 2019
VA IPA- YILING XU
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
May 2015 – May 2018
AN OPEN LABEL STUDY TO ASSESS THE SAFETY AND EFFICACY OFCOR-003 (2S, 4R-KETOCONAZOLE) IN THE TREATMENT OF ENDOGENOUS Cushing's Syndrome
Role: Principal Investigator
Funding: STRONGBRIDGE BIOPHARMA

Education

Fellowship – Endocrinology, Diabetes and Metabolism
2008 · University of Texas
Residency – Internal Medicine
2005 · Johns Hopkins University
Doctor of Osteopathic Medicine
2002 · University of North Texas

Contact Details

Phones:
Business:
(352) 273-8656
Emails:
Addresses:
Business Mailing:
PO Box 100226
GAINESVILLE FL 32610
Business Street:
1600 SW ARCHER RD H2
GAINESVILLE FL 32610