Maria A Grant,
Professor
Teaching Profile
Courses Taught
2011-2012
DEN6262 Prin of Pharmacology
2007-2010
PHA4904 Pharmacology Research
2010
BMS6404 Pharmacology
Publications
2014
Truncated Cables1 causes agenesis of the corpus callosum in mice.
Laboratory investigation; a journal of technical methods and pathology.
94(3):321-30
[DOI] 10.1038/labinvest.2013.146.
[PMID] 24336072.
2012
ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy.
Molecular therapy : the journal of the American Society of Gene Therapy.
20(1):28-36
[DOI] 10.1038/mt.2011.155.
[PMID] 21792177.
2012
Arginyl-glutamine dipeptide or docosahexaenoic acid attenuates hyperoxia-induced small intestinal injury in neonatal mice.
Journal of pediatric gastroenterology and nutrition.
54(4):499-504
[DOI] 10.1097/MPG.0b013e3182330867.
[PMID] 22020559.
2012
Autophagy in the retina: a potential role in age-related macular degeneration.
Advances in experimental medicine and biology.
723:83-90
[DOI] 10.1007/978-1-4614-0631-0_12.
[PMID] 22183319.
2012
Long-term effects of intravitreal injection of GMP-grade bone-marrow-derived CD34+ cells in NOD-SCID mice with acute ischemia-reperfusion injury.
Investigative ophthalmology & visual science.
53(2):986-94
[DOI] 10.1167/iovs.11-8833.
[PMID] 22247454.
2012
Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis.
Circulation research.
110(10):1322-35
[DOI] 10.1161/CIRCRESAHA.112.268029.
[PMID] 22474255.
2012
Nerve growth factor promotes endothelial progenitor cell-mediated angiogenic responses.
Investigative ophthalmology & visual science.
53(4):2030-7
[DOI] 10.1167/iovs.11-8430.
[PMID] 22410557.
2012
Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3.
PloS one.
7(7)
[DOI] 10.1371/journal.pone.0039398.
[PMID] 22792172.
2012
Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice.
Blood.
119(2):629-36
[DOI] 10.1182/blood-2011-04-346007.
[PMID] 22028476.
2012
γ-Secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines.
Investigative ophthalmology & visual science.
53(2):574-85
[DOI] 10.1167/iovs.11-8728.
[PMID] 22205609.
2011
An Ace2 Activator (Dize) Improves Endothelial Progenitor Cell Function and Attenuates Pulmonary Hypertension
Hypertension.
58
2011
Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cells.
Investigative ophthalmology & visual science.
52(8):5093-104
[DOI] 10.1167/iovs.10-70911.
[PMID] 21676908.
2011
Endothelial dysfunction as a potential contributor in diabetic nephropathy.
Nature reviews. Nephrology.
7(1):36-44
[DOI] 10.1038/nrneph.2010.152.
[PMID] 21045790.
2011
Impaired Cd34(+) Endothelial Progenitor Cell Function in Individuals With Pulmonary Hypertension Is Restored By the Activation of Ace2/Angiotensin-(1-7)/Mas Pathway
Hypertension.
58
2011
PEDF regulates vascular permeability by a γ-secretase-mediated pathway.
PloS one.
6(6)
[DOI] 10.1371/journal.pone.0021164.
[PMID] 21695048.
2011
Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide.
Endocrinology.
152(7):2786-96
[DOI] 10.1210/en.2010-1126.
[PMID] 21558316.
2011
Selective blockade of cytoskeletal actin remodeling reduces experimental choroidal neovascularization.
Investigative ophthalmology & visual science.
52(5):2490-6
[DOI] 10.1167/iovs.10-6351.
[PMID] 21178140.
2011
The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy.
The Journal of biological chemistry.
286(11):9542-54
[DOI] 10.1074/jbc.M110.198689.
[PMID] 21212276.
2011
The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models.
Diabetes.
60(9):2370-8
[DOI] 10.2337/db10-0550.
[PMID] 21771974.
2010
Activation of the Protective Arm of Renin Angiotensin System (Ras) Corrects the Reparative Dysfunction of Diabetic Cd34+Cells
Blood.
116:1087-1088
2010
Inhibition of Plasminogen Activator Inhibitor (Pai)-1 Corrects Diabetic Cd34(+) Dysfunction
Blood.
116
2010
Insulin-Like Growth Factor Binding Protein-3 (Igfbp-3) Improves Vascular Permeability By Reducing Acid Sphingomyelinase (Asm).
Endocrine Reviews.
31
2010
Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization.
Investigative ophthalmology & visual science.
51(5):2697-704
[DOI] 10.1167/iovs.09-4137.
[PMID] 20007826.
2010
Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice.
American journal of physiology. Renal physiology.
298(3):F609-16
[DOI] 10.1152/ajprenal.00377.2009.
[PMID] 20015944.
2010
Targeting retinal and choroid neovascularization using the small molecule inhibitor carboxyamidotriazole.
Brain research bulletin.
81(2-3):320-6
[DOI] 10.1016/j.brainresbull.2009.08.001.
[PMID] 19679174.
2010
The promise of cell-based therapies for diabetic complications: challenges and solutions.
Circulation research.
106(5):854-69
[DOI] 10.1161/CIRCRESAHA.109.213140.
[PMID] 20299675.
2009
Delivery of antioxidant enzyme genes to protect against ischemia/reperfusion-induced injury to retinal microvasculature.
Investigative ophthalmology & visual science.
50(12):5587-95
[DOI] 10.1167/iovs.09-3633.
[PMID] 19628743.
2009
Delivery of Antioxidant Genes Protects Retinal Microvasculature From Ischemia/Reperfusion Injury
Molecular Therapy.
17
2009
Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock.
The Journal of experimental medicine.
206(13):2897-906
[DOI] 10.1084/jem.20090889.
[PMID] 19934019.
2009
Differential Paracrine Dysfunction and Hypoxic Desensitization in Diabetic Cd34+and Cd14+Bone Marrow Derived Cells (Bmdc)
Circulation.
120
2009
Igf Binding Protein-3 (Igfbp3) Affects Endothelial Cell Ensheathment in the Oxygen Induced Retinopathy (Oir) Model
Journal of vascular research (Online).
46
2009
Insulin-Like Growth Factor Binding Protein-3 (Igfbp3) Modulates Vascular Tone Via Scavenging Receptor-B1 (Srb1)-Dependent Nitric Oxide Release
Circulation.
120
2009
Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation.
Circulation research.
105(9):897-905
[DOI] 10.1161/CIRCRESAHA.109.199059.
[PMID] 19762684.
2009
Lack of Nitric Oxide Results in Increased Glomerular Capillary Basement Membrane Thickness
Microscopy and Microanalysis.
15(S2):852-853
[DOI] 10.1017/S1431927609093489.
2009
Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies.
Journal of lipid research.
50(11):2245-57
[DOI] 10.1194/jlr.M900048-JLR200.
[PMID] 19509417.
2009
Retinal endothelial cell apoptosis stimulates recruitment of endothelial progenitor cells.
Investigative ophthalmology & visual science.
50(10):4967-73
[DOI] 10.1167/iovs.09-3616.
[PMID] 19474402.
2009
Transient Blockade of Tgf-Beta in Hematopoietic Stem Cells and Cd34+Endothelial Precursor Cells Enhances Survival, Proliferation and Reparative Functions in Response To Ischemic Vascular Injury
Circulation.
120
2009
Transient Inhibition of Transforming Growth Factor-Beta 1 in Human Blood-Derived Cd34+Cells Enhances Survival and Proliferation in Vitro and Vascular Reparative Functions in Vivo
Blood.
114
2009
Vision: New light on allergy receptor.
Nature.
460(7252):182-3
[DOI] 10.1038/460182a.
[PMID] 19587753.
2008
Accelerated Repair of Vascular Injury in Diabetes By Tgf-Beta 1 Modified Hematopoietic Stem Cells (Hsc).
Blood.
112
2008
Characterization of Intraocular Immunopathology Following Intracameral Inoculation With Alloantigen
Molecular Vision.
14:615-624
2008
Erythropoietin: when liability becomes asset in neurovascular repair.
The Journal of clinical investigation.
118(2):467-70
[DOI] 10.1172/JCI34643.
[PMID] 18219388.
2008
gamma-Secretase: a multifaceted regulator of angiogenesis.
Journal of cellular and molecular medicine.
12(3):781-95
[DOI] 10.1111/j.1582-4934.2008.00274.x.
[PMID] 18266961.
2008
Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators.
Diabetes.
57(7):1952-65
[DOI] 10.2337/db07-1520.
[PMID] 18420487.
2008
Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites.
Molecular and cellular biochemistry.
316(1-2):177-86
[DOI] 10.1007/s11010-008-9831-4.
[PMID] 18612802.
2008
Insulin Like Growth Factor Binding Protein-3 (Igfbp-3) Mediates Vascular Repair By Hdl Receptor Activation and Sphingosine Kinase (Sk-1)/Sphingosine 1-Phosphate (S1P) Dependent Nitric Oxide (No) Generation
Circulation.
118
2008
Long-term engraftment of bone marrow-derived cells in the intimal hyperplasia lesion of autologous vein grafts.
The American journal of pathology.
172(3):839-48
[DOI] 10.2353/ajpath.2008.070840.
[PMID] 18276778.
2008
Myogenic tone and reactivity of cerebral arteries in type II diabetic BBZDR/Wor rat.
European journal of pharmacology.
579(1-3):298-307
[PMID] 18036520.
2008
Nonpeptide somatostatin receptor agonists specifically target ocular neovascularization via the somatostatin type 2 receptor.
Investigative ophthalmology & visual science.
49(11):5094-102
[DOI] 10.1167/iovs.08-2289.
[PMID] 18599562.
2008
SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation.
Microvascular research.
75(3):302-7
[DOI] 10.1016/j.mvr.2007.12.001.
[PMID] 18234239.
2008
Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats.
The Journal of pharmacology and experimental therapeutics.
324(3):894-901
[PMID] 18083913.
2008
The Role of Acaid and Cd4(+)Cd25(+)Foxp3(+) Regulatory T Cells On Ctl Function Against Mhc Alloantigens
Molecular Vision.
14:2435-2442
2006
Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes.
Diabetes.
55(1):102-9
[PMID] 16380482.
2003
Expression of IGFBP-3 by human retinal endothelial cell cultures: IGFBP-3 involvement in growth inhibition and apoptosis.
Investigative ophthalmology & visual science.
44(1):365-9
[PMID] 12506097.
2001
Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation.
Investigative ophthalmology & visual science.
42(9):2068-73
[PMID] 11481274.
2000
Plasminogen activator inhibitor (PAI)-1 overexpression in retinal microvessels of PAI-1 transgenic mice.
Investigative ophthalmology & visual science.
41(8):2296-302
[PMID] 10892876.
2000
The efficacy of octreotide in the therapy of severe nonproliferative and early proliferative diabetic retinopathy: a randomized controlled study.
Diabetes care.
23(4):504-9
[PMID] 10857943.
1999
Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells.
Circulation research.
85(8):699-706
[PMID] 10521243.
1998
Fibronectin fragments modulate human retinal capillary cell proliferation and migration.
Diabetes.
47(8):1335-40
[PMID] 9703336.
1998
Matrix metalloproteinase expression in human retinal microvascular cells.
Diabetes.
47(8):1311-7
[PMID] 9703333.
Grants
Mar 2012
– Aug 2020
UFRCC for Cardiovascular Cell Therapy Research Network
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Mar 2011
– Feb 2017
CVD Protection Mechanism involving ACE2/ANG-(1-7) Axis
Role: Project Manager
Funding: NATL INST OF HLTH
May 2010
– Apr 2016
Angiotensin-Converting Enzyme2 in Vascular Endothelial Function
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Contact Details
Phones:
- Business:
- (352) 871-4314
Emails:
- Business:
- grantma@ufl.edu
Addresses:
- Business Mailing:
-
4828 E 300 N
FRANKLIN FL 46131 - Business Street:
-
4828 E 300 N
FRANKLIN FL 46131