Maria A Grant

Maria A Grant,

Professor

Department: MD-ENDOCRINOLOGY
Business Phone: (352) 871-4314
Business Email: grantma@ufl.edu

Teaching Profile

Courses Taught
2011-2012
DEN6262 Prin of Pharmacology
2007-2010
PHA4904 Pharmacology Research
2010
BMS6404 Pharmacology

Publications

2014
Truncated Cables1 causes agenesis of the corpus callosum in mice.
Laboratory investigation; a journal of technical methods and pathology. 94(3):321-30 [DOI] 10.1038/labinvest.2013.146. [PMID] 24336072.
2012
Ace2 and Ang-(1-7) Confer Protection Against Development of Diabetic Retinopathy
Molecular Therapy. 20(1):28-36 [DOI] 10.1038/mt.2011.155. [PMID] 21792177.
2012
Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice.
Nutrition (Burbank, Los Angeles County, Calif.). 28(11-12):1186-91 [DOI] 10.1016/j.nut.2012.04.001. [PMID] 23044165.
2012
Arginyl-Glutamine Dipeptide Or Docosahexaenoic Acid Attenuates Hyperoxia-Induced Small Intestinal Injury in Neonatal Mice
Journal of Pediatric Gastroenterology and Nutrition. 54(4):499-504 [DOI] 10.1097/MPG.0b013e3182330867. [PMID] 22020559.
2012
Autophagy in the Retina: a Potential Role in Age-Related Macular Degeneration
Advances in experimental medicine and biology. 723:83-90 [DOI] 10.1007/978-1-4614-0631-0\_12. [PMID] 22183319.
2012
Bone marrow-CNS connections: implications in the pathogenesis of diabetic retinopathy.
Progress in retinal and eye research. 31(5):481-94 [DOI] 10.1016/j.preteyeres.2012.04.005. [PMID] 22609081.
2012
Brain-mediated dysregulation of the bone marrow activity in angiotensin II-induced hypertension.
Hypertension (Dallas, Tex. : 1979). 60(5):1316-23 [DOI] 10.1161/HYPERTENSIONAHA.112.199547. [PMID] 23045460.
2012
Gamma-Secretase Inhibition of Murine Choroidal Neovascularization Is Associated With Reduction of Superoxide and Proinflammatory Cytokines
Investigative Ophthalmology & Visual Science. 53(2):574-585 [DOI] 10.1167/iovs.11-8728. [PMID] 22205609.
2012
Long-term effects of intravitreal injection of GMP-grade bone-marrow-derived CD34+ cells in NOD-SCID mice with acute ischemia-reperfusion injury.
Investigative ophthalmology & visual science. 53(2):986-94 [DOI] 10.1167/iovs.11-8833. [PMID] 22247454.
2012
Loss of Angiotensin-Converting Enzyme-2 Exacerbates Diabetic Cardiovascular Complications and Leads To Systolic and Vascular Dysfunction a Critical Role of the Angiotensin Ii/At1 Receptor Axis
Circulation research. 110(10):1322-U146 [DOI] 10.1161/CIRCRESAHA.112.268029. [PMID] 22474255.
2012
Nerve Growth Factor Promotes Endothelial Progenitor Cell-Mediated Angiogenic Responses
Investigative Ophthalmology & Visual Science. 53(4):2030-2037 [DOI] 10.1167/iovs.11-8430. [PMID] 22410557.
2012
Protection of Blood Retinal Barrier and Systemic Vasculature By Insulin-Like Growth Factor Binding Protein-3
PLoS One. 7(7) [DOI] 10.1371/journal.pone.0039398. [PMID] 22792172.
2012
Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice.
Blood. 119(2):629-36 [DOI] 10.1182/blood-2011-04-346007. [PMID] 22028476.
2012
Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers.
International journal of antimicrobial agents. 40(1):51-4 [DOI] 10.1016/j.ijantimicag.2012.03.006. [PMID] 22584101.
2012
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
EMBO molecular medicine. 4(9):980-91 [DOI] 10.1002/emmm.201101084. [PMID] 22903875.
2011
An Ace2 Activator (Dize) Improves Endothelial Progenitor Cell Function and Attenuates Pulmonary Hypertension
Hypertension. 58
2011
Blockade of Nadph Oxidase Restores Vasoreparative Function in Diabetic Cd34(+) Cells
Investigative Ophthalmology & Visual Science. 52(8):5093-5104 [DOI] 10.1167/iovs.10-70911. [PMID] 21676908.
2011
Cell-based therapies for diabetic retinopathy.
Current diabetes reports. 11(4):265-74 [DOI] 10.1007/s11892-011-0197-8. [PMID] 21611766.
2011
Endothelial Dysfunction as a Potential Contributor in Diabetic Nephropathy
Nature reviews. Nephrology. 7(1):36-44 [DOI] 10.1038/nrneph.2010.152. [PMID] 21045790.
2011
Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase).
Investigative ophthalmology & visual science. 52(11):8278-86 [DOI] 10.1167/iovs.11-8167. [PMID] 21931131.
2011
Impaired Cd34(+) Endothelial Progenitor Cell Function in Individuals With Pulmonary Hypertension Is Restored By the Activation of Ace2/Angiotensin-(1-7)/Mas Pathway
Hypertension. 58
2011
Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury.
The American journal of pathology. 178(4):1517-28 [DOI] 10.1016/j.ajpath.2010.12.031. [PMID] 21435441.
2011
Pedf Regulates Vascular Permeability By a Gamma-Secretase-Mediated Pathway
PLoS One. 6(6) [DOI] 10.1371/journal.pone.0021164. [PMID] 21695048.
2011
Placenta growth factor-1 exerts time-dependent stabilization of adherens junctions following VEGF-induced vascular permeability.
PloS one. 6(3) [DOI] 10.1371/journal.pone.0018076. [PMID] 21464949.
2011
Relaxin Induces Rapid Dilation of Rodent Small Renal and Human Subcutaneous Arteries Via Pi3 Kinase and Nitric Oxide
Endocrinology. 152(7):2786-2796 [DOI] 10.1210/en.2010-1126. [PMID] 21558316.
2011
Selective Blockade of Cytoskeletal Actin Remodeling Reduces Experimental Choroidal Neovascularization
Investigative Ophthalmology & Visual Science. 52(5):2490-2496 [DOI] 10.1167/iovs.10-6351. [PMID] 21178140.
2011
The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy.
The Journal of biological chemistry. 286(11):9542-54 [DOI] 10.1074/jbc.M110.198689. [PMID] 21212276.
2011
The Unconventional Role of Acid Sphingomyelinase in Regulation of Retinal Microangiopathy in Diabetic Human and Animal Models
Diabetes. 60(9):2370-2378 [DOI] 10.2337/db10-0550. [PMID] 21771974.
2011
Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species.
Cardiovascular research. 91(1):171-9 [DOI] 10.1093/cvr/cvr059. [PMID] 21354995.
2011
γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.
The Journal of biological chemistry. 286(49):42514-42523 [DOI] 10.1074/jbc.M111.296590. [PMID] 22016384.
2010
Activation of the Protective Arm of Renin Angiotensin System (Ras) Corrects the Reparative Dysfunction of Diabetic Cd34+Cells
Blood. 116:1087-1088
2010
Diabetic eNOS-knockout mice develop accelerated retinopathy.
Investigative ophthalmology & visual science. 51(10):5240-6 [DOI] 10.1167/iovs.09-5147. [PMID] 20435587.
2010
EPCs and pathological angiogenesis: when good cells go bad.
Microvascular research. 79(3):207-16 [DOI] 10.1016/j.mvr.2010.02.011. [PMID] 20188747.
2010
Inhibition of Plasminogen Activator Inhibitor (Pai)-1 Corrects Diabetic Cd34(+) Dysfunction
Blood. 116
2010
Insulin-Like Growth Factor Binding Protein-3 (Igfbp-3) Improves Vascular Permeability By Reducing Acid Sphingomyelinase (Asm).
Endocrine Reviews. 31
2010
Paracrine Modulation of Cxcr4 By Igf-1 and Vegf: Implications for Choroidal Neovascularization
Investigative Ophthalmology & Visual Science. 51(5):2697-2704 [DOI] 10.1167/iovs.09-4137. [PMID] 20007826.
2010
Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice.
American journal of physiology. Renal physiology. 298(3):F609-16 [DOI] 10.1152/ajprenal.00377.2009. [PMID] 20015944.
2010
Targeting retinal and choroid neovascularization using the small molecule inhibitor carboxyamidotriazole.
Brain research bulletin. 81(2-3):320-6 [DOI] 10.1016/j.brainresbull.2009.08.001. [PMID] 19679174.
2010
The promise of cell-based therapies for diabetic complications: challenges and solutions.
Circulation research. 106(5):854-69 [DOI] 10.1161/CIRCRESAHA.109.213140. [PMID] 20299675.
2009
Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization.
Experimental eye research. 88(3):367-77 [DOI] 10.1016/j.exer.2008.07.012. [PMID] 18723015.
2009
Delivery of Antioxidant Enzyme Genes To Protect Against Ischemia/Reperfusion-Induced Injury To Retinal Microvasculature
Investigative Ophthalmology & Visual Science. 50(12):5587-5595 [DOI] 10.1167/iovs.09-3633. [PMID] 19628743.
2009
Delivery of Antioxidant Genes Protects Retinal Microvasculature From Ischemia/Reperfusion Injury
Molecular Therapy. 17
2009
Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock.
The Journal of experimental medicine. 206(13):2897-906 [DOI] 10.1084/jem.20090889. [PMID] 19934019.
2009
Differential Paracrine Dysfunction and Hypoxic Desensitization in Diabetic Cd34+and Cd14+Bone Marrow Derived Cells (Bmdc)
Circulation. 120
2009
Igf Binding Protein-3 (Igfbp3) Affects Endothelial Cell Ensheathment in the Oxygen Induced Retinopathy (Oir) Model
Journal of vascular research (Online). 46
2009
Insulin-Like Growth Factor Binding Protein-3 (Igfbp3) Modulates Vascular Tone Via Scavenging Receptor-B1 (Srb1)-Dependent Nitric Oxide Release
Circulation. 120
2009
Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair By Enhancing Nitric Oxide Generation
Circulation research. 105(9):897-U174 [DOI] 10.1161/CIRCRESAHA.109.199059. [PMID] 19762684.
2009
Labeling of stem cells with monocrystalline iron oxide for tracking and localization by magnetic resonance imaging.
Microvascular research. 78(1):132-9 [DOI] 10.1016/j.mvr.2009.03.007. [PMID] 19345699.
2009
Lack of Nitric Oxide Results in Increased Glomerular Capillary Basement Membrane Thickness
Microscopy and Microanalysis. 15(S2):852-853 [DOI] 10.1017/S1431927609093489.
2009
Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies.
Journal of lipid research. 50(11):2245-57 [DOI] 10.1194/jlr.M900048-JLR200. [PMID] 19509417.
2009
Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair.
Molecular therapy : the journal of the American Society of Gene Therapy. 17(9):1594-604 [DOI] 10.1038/mt.2009.145. [PMID] 19584817.
2009
Retinal endothelial cell apoptosis stimulates recruitment of endothelial progenitor cells.
Investigative ophthalmology & visual science. 50(10):4967-73 [DOI] 10.1167/iovs.09-3616. [PMID] 19474402.
2009
Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis.
Antimicrobial agents and chemotherapy. 53(7):2773-6 [DOI] 10.1128/AAC.01409-08. [PMID] 19364847.
2009
Transient Blockade of Tgf-Beta in Hematopoietic Stem Cells and Cd34+Endothelial Precursor Cells Enhances Survival, Proliferation and Reparative Functions in Response To Ischemic Vascular Injury
Circulation. 120
2009
Transient Inhibition of Transforming Growth Factor-Beta 1 in Human Blood-Derived Cd34+Cells Enhances Survival and Proliferation in Vitro and Vascular Reparative Functions in Vivo
Blood. 114
2009
Vision: New light on allergy receptor.
Nature. 460(7252):182-3 [DOI] 10.1038/460182a. [PMID] 19587753.
2008
Accelerated Repair of Vascular Injury in Diabetes By Tgf-Beta 1 Modified Hematopoietic Stem Cells (Hsc).
Blood. 112
2008
Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes.
Diabetes. 57(9):2488-94 [DOI] 10.2337/db08-0381. [PMID] 18559661.
2008
Characterization of Intraocular Immunopathology Following Intracameral Inoculation With Alloantigen
Molecular Vision. 14:615-624
2008
Erythropoietin: When Liability Becomes Asset in Neurovascular Repair
The Journal of clinical investigation. 118(2):467-470 [DOI] 10.1172/JCI34643. [PMID] 18219388.
2008
Gamma-Secretase: a Multifaceted Regulator of Angiogenesis
Journal of Cellular and Molecular Medicine. 12(3):781-795 [DOI] 10.1111/j.1582-4934.2008.00274.x. [PMID] 18266961.
2008
Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators.
Diabetes. 57(7):1952-65 [DOI] 10.2337/db07-1520. [PMID] 18420487.
2008
Inhibition of Protein Kinase Ck2 Suppresses Angiogenesis and Hematopoietic Stem Cell Recruitment To Retinal Neovascularization Sites
Molecular and cellular biochemistry. 316(1-2):177-186 [DOI] 10.1007/s11010-008-9831-4. [PMID] 18612802.
2008
Insulin Like Growth Factor Binding Protein-3 (Igfbp-3) Mediates Vascular Repair By Hdl Receptor Activation and Sphingosine Kinase (Sk-1)/Sphingosine 1-Phosphate (S1P) Dependent Nitric Oxide (No) Generation
Circulation. 118
2008
Long-Term Engraftmetn of Bone Marrow-Derived Cells in the Intimal Hyperplasia Lesion of Autologous Vein Grafts
The American Journal Of Pathology. 172(3):839-848 [DOI] 10.2353/ajpath.2008.070840. [PMID] 18276778.
2008
Myogenic Tone and Reactivity of Cerebral Arteries in Type Ii Diabetic Bbzdr/Wor Rat
European Journal of Pharmacology. 579(1-3):298-307 [DOI] 10.1016/j.ejphar.2007.10.028. [PMID] 18036520.
2008
Nonpeptide Somatostatin Receptor Agonists Specifically Target Ocular Neovascularization Via the Somatostatin Type 2 Receptor
Investigative Ophthalmology & Visual Science. 49(11):5094-5102 [DOI] 10.1167/iovs.08-2289. [PMID] 18599562.
2008
Sdf1-Alpha Is Associated With Vegfr-2 in Human Choroidal Neovascularisation
Microvascular research MVR. 75(3):302-307 [DOI] 10.1016/j.mvr.2007.12.001. [PMID] 18234239.
2008
Studies With An Orally Bioavailable Alpha(V) Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats
Journal of Pharmacology and Experimental Therapeutics. 324(3):894-901 [DOI] 10.1124/jpet.107.131656. [PMID] 18083913.
2008
The Role of Acaid and Cd4(+)Cd25(+)Foxp3(+) Regulatory T Cells On Ctl Function Against Mhc Alloantigens
Molecular Vision. 14:2435-2442
2007
Adenoviruses increase endothelial cell proliferation, migration, and tube formation: partial reversal by the focal adhesion kinase inhibitor, FRNK.
Microvascular research. 73(3):157-62 [PMID] 17407784.
2006
Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes.
Diabetes. 55(1):102-9 [DOI] 10.2337/diabetes.55.01.06.db05-0803. [PMID] 16380482.
2006
Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome.
Blood. 107(5):1908-15 [PMID] 16254142.
2004
The role of growth factors in the pathogenesis of diabetic retinopathy.
Expert opinion on investigational drugs. 13(10):1275-93 [PMID] 15461557.
2003
Expression of IGFBP-3 by human retinal endothelial cell cultures: IGFBP-3 involvement in growth inhibition and apoptosis.
Investigative Ophthalmology & Visual Science. 44(1):365-9 [DOI] 10.1167/iovs.02-0309. [PMID] 12506097.
2003
Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.
Nature structural biology. 10(9):751-6 [PMID] 12923575.
2002
Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization.
Nature medicine. 8(6):607-12 [PMID] 12042812.
2002
Somatostatin analogues as drug therapies for retinopathies.
Drugs of today (Barcelona, Spain : 1998). 38(11):783-91 [PMID] 12582462.
2001
Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation.
Investigative Ophthalmology & Visual Science. 42(9):2068-73 [PMID] 11481274.
2000
Plasminogen activator inhibitor (PAI)-1 overexpression in retinal microvessels of PAI-1 transgenic mice.
Investigative ophthalmology & visual science. 41(8):2296-302 [PMID] 10892876.
2000
The efficacy of octreotide in the therapy of severe nonproliferative and early proliferative diabetic retinopathy: a randomized controlled study.
Diabetes Care. 23(4):504-9 [DOI] 10.2337/diacare.23.4.504. [PMID] 10857943.
1999
Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells.
Circulation research. 85(8):699-706 [PMID] 10521243.
1999
Expression of IGF-1, IGF-1 receptor and TGF-beta following balloon angioplasty in atherosclerotic and normal rabbit iliac arteries: an immunocytochemical study.
Regulatory peptides. 79(1):47-53 [PMID] 9930582.
1998
Fibronectin fragments modulate human retinal capillary cell proliferation and migration.
Diabetes. 47(8):1335-40 [DOI] 10.2337/diabetes.47.8.1335. [PMID] 9703336.
1998
Matrix metalloproteinase expression in human retinal microvascular cells.
Diabetes. 47(8):1311-7 [DOI] 10.2337/diabetes.47.8.1311. [PMID] 9703333.

Grants

Mar 2012 – Aug 2020
UFRCC for Cardiovascular Cell Therapy Research Network
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Mar 2011 – Feb 2017
CVD Protection Mechanism involving ACE2/ANG-(1-7) Axis
Role: Project Manager
Funding: NATL INST OF HLTH
May 2010 – Apr 2016
Angiotensin-Converting Enzyme2 in Vascular Endothelial Function
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI

Contact Details

Phones:
Business:
(352) 871-4314
Emails:
Business:
grantma@ufl.edu
Addresses:
Business Mailing:
4828 E 300 N
FRANKLIN FL 46131
Business Street:
4828 E 300 N
FRANKLIN FL 46131