Peter W Stacpoole, MD, Ph.D
Professor
About Peter W Stacpoole
Dr. Stacpoole received his Ph.D. in 1972, from the University of California at San Francisco. He received his MD degree in 1976, from Vanderbilt University in Nashville, Tennessee. He also completed his internship and residency (1976-1978) training in Internal Medicine and Endocrinology Fellowship (1978-1980) training at Vanderbilt University. In 1980, Dr. Stacpoole became a member of the Department of Medicine at the University of Florida, where he is a Professor of Medicine, Biochemistry and Molecular Biology.
Teaching Profile
Courses Taught
2020-2022
PAS5010 Intro to Medicine 1
2018
MDC7200 Medicine Clerkship
2018
MDC7203 Senior Medicine Clerk
2009
IDH4917 Undergrad Research
2006
GMS6181 Spec Topics Microbiol
2023
GMS6622 Mitochondrial Biology in Aging and Disease
Clinical Profile
Specialties
- Endocrinology, Diabetes and Metabolism
- Endocrinology, Diabetes and Metabolism
Research Profile
Dr. Stacpoole’s federally-sponsored research is broadly focused in two areas: intermediary metabolism and new drug development, with particular emphasis on the causes and treatment of congenital and acquired mitochondrial diseases. In this regard, he collaborates with investigators at UF and across N. America with expertise in neurology, physiology, oncology, immunology, and cell and molecular biology.
Related research includes mechanistically oriented laboratory studies on the molecular and biochemical consequences of loss of function mutations in the mitochondrial pyruvate dehydrogenase complex (PDC) and therapeutic interventions for congenital and acquired causes of PDC deficiency.
With regard to new drug development, Dr. Stacpoole and his colleagues have developed a prototype for a novel class of investigational drugs for the treatment of acquired or inborn errors of mitochondrial energy metabolism and lactic acidosis. The prototype of this class, dichloroacetate (DCA), is currently undergoing two federally funded FDA-approved multicenter clinical trials: a Phase 3 trial of DCA in children with congenital defects in the PDC and a Phase 2A trial of DCA in adults with recurrent glioblastoma multiforme (GBM), the most common and deadly primary brain cancer in adults. Dr. Stacpoole and colleagues are also conducting preclinical studies in the therapeutic potential of DCA in Barth syndrome, a rare mitochondrial pediatric disease, in neonatal stress during parturition and in septic shock, a major cause of mortality in hospitalized patients.
Open Researcher and Contributor ID (ORCID)
0000-0003-0680-5881
Publications
2023
Clinical physiology and pharmacology of GSTZ1/MAAI.
Biochemical pharmacology.
217
[DOI] 10.1016/j.bcp.2023.115818.
[PMID] 37742772.
2023
In-vivo magnetic resonance spectroscopy of lactate as a non-invasive biomarker of dichloroacetate activity in cancer and non-cancer central nervous system disorders.
Frontiers in oncology.
13
[DOI] 10.3389/fonc.2023.1077461.
[PMID] 37007074.
2023
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat.
Mitochondrion.
70:59-102
[DOI] 10.1016/j.mito.2023.02.007.
[PMID] 36863425.
2022
Dichloroacetate improves systemic energy balance and feeding behavior during sepsis.
JCI insight.
7(12)
[DOI] 10.1172/jci.insight.153944.
[PMID] 35730570.
2022
Sepsis, pyruvate, and mitochondria energy supply chain shortage.
Journal of leukocyte biology.
112(6):1509-1514
[DOI] 10.1002/JLB.3MR0322-692RR.
[PMID] 35866365.
2022
Sodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor.
American journal of physiology. Regulatory, integrative and comparative physiology.
322(1):R83-R98
[DOI] 10.1152/ajpregu.00185.2021.
[PMID] 34851727.
2021
Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction.
eLife.
10
[DOI] 10.7554/eLife.64611.
[PMID] 33616039.
2020
Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.
Drug metabolism and disposition: the biological fate of chemicals.
48(7):563-569
[DOI] 10.1124/dmd.120.090639.
[PMID] 32357971.
2020
Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.
Drug metabolism and disposition: the biological fate of chemicals.
48(11):1217-1223
[DOI] 10.1124/dmd.120.000142.
[PMID] 32873593.
2020
Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1.
Drug metabolism and disposition: the biological fate of chemicals.
48(11):1224-1230
[DOI] 10.1124/dmd.120.000143.
[PMID] 32873592.
2020
Mitochondrial diseases in North America: An analysis of the NAMDC Registry.
Neurology. Genetics.
6(2)
[DOI] 10.1212/NXG.0000000000000402.
[PMID] 32337332.
2020
Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses.
Drug metabolism and disposition: the biological fate of chemicals.
49(6):451-458
[DOI] 10.1124/dmd.120.000330.
[PMID] 33811107.
2020
Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes.
Journal of leukocyte biology.
107(3):467-484
[DOI] 10.1002/JLB.3A1119-236R.
[PMID] 31894617.
2020
The changing landscape of clinical trials for mitochondrial diseases: 2011 to present.
Mitochondrion.
50:51-57
[DOI] 10.1016/j.mito.2019.10.010.
[PMID] 31669619.
2019
Dichloroacetate-induced peripheral neuropathy.
International review of neurobiology.
145:211-238
[DOI] 10.1016/bs.irn.2019.05.003.
[PMID] 31208525.
2019
Mitochondrial Glutathione Transferase Zeta 1 Is Inactivated More Rapidly by Dichloroacetate than the Cytosolic Enzyme in Adult and Juvenile Rat Liver.
Chemical research in toxicology.
32(10):2042-2052
[DOI] 10.1021/acs.chemrestox.9b00207.
[PMID] 31524376.
2018
Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.
Drug metabolism and disposition: the biological fate of chemicals.
46(8):1118-1128
[DOI] 10.1124/dmd.118.081810.
[PMID] 29853471.
2018
Development of a novel observer reported outcome tool as the primary efficacy outcome measure for a rare disease randomized controlled trial.
Mitochondrion.
42:59-63
[DOI] 10.1016/j.mito.2017.11.003.
[PMID] 29129554.
2018
Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.
Journal of clinical pharmacology.
58(2):212-220
[DOI] 10.1002/jcph.1009.
[PMID] 28914978.
2018
Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay.
Genetic testing and molecular biomarkers.
22(4):266-269
[DOI] 10.1089/gtmb.2017.0261.
[PMID] 29641284.
2018
Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.
JCI insight.
3(15)
[DOI] 10.1172/jci.insight.99292.
[PMID] 30089711.
2018
Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration.
Biochemical pharmacology.
152:236-243
[DOI] 10.1016/j.bcp.2018.04.001.
[PMID] 29626439.
2017
Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society.
Genetics in medicine : official journal of the American College of Medical Genetics.
19(12)
[DOI] 10.1038/gim.2017.107.
[PMID] 28749475.
2017
Response to Newman et al.
Genetics in medicine : official journal of the American College of Medical Genetics.
19(12)
[DOI] 10.1038/gim.2017.164.
[PMID] 29215644.
2017
Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.
Pharmacology & therapeutics.
170:166-180
[DOI] 10.1016/j.pharmthera.2016.10.018.
[PMID] 27771434.
2017
Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.
Journal of the National Cancer Institute.
109(11)
[DOI] 10.1093/jnci/djx071.
[PMID] 29059435.
2016
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.
Biochimica et biophysica acta.
1860(6):1202-10
[DOI] 10.1016/j.bbagen.2016.01.024.
[PMID] 26850694.
2016
Pharmacogenetic considerations with dichloroacetate dosing.
Pharmacogenomics.
17(7):743-53
[DOI] 10.2217/pgs-2015-0012.
[PMID] 27143230.
2016
Vitamin B6 nutritional status and cellular availability of pyridoxal 5′-phosphate govern the function of the transsulfuration pathway’s canonical reactions and hydrogen sulfide production via side reactions.
Biochimie.
126:21-6
[DOI] 10.1016/j.biochi.2015.12.020.
[PMID] 26765812.
2015
Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.
Drug metabolism and personalized therapy.
30(1):49-55
[DOI] 10.1515/dmdi-2014-0015.
[PMID] 25283137.
2015
Chloride concentrations in human hepatic cytosol and mitochondria are a function of age.
Biochemical and biophysical research communications.
459(3):463-8
[DOI] 10.1016/j.bbrc.2015.02.128.
[PMID] 25748576.
2015
Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.
Journal of clinical pharmacology.
55(1):50-5
[DOI] 10.1002/jcph.371.
[PMID] 25079374.
2015
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes.
The Journal of nutrition.
145(1):87-95
[DOI] 10.3945/jn.114.201095.
[PMID] 25527663.
2015
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
The American journal of clinical nutrition.
102(3):616-25
[DOI] 10.3945/ajcn.115.113159.
[PMID] 26201817.
2015
The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.
Pharmacogenetics and genomics.
25(5):239-45
[DOI] 10.1097/FPC.0000000000000129.
[PMID] 25738370.
2014
Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.
Chemico-biological interactions.
215:33-9
[DOI] 10.1016/j.cbi.2014.02.015.
[PMID] 24632415.
2014
Dichloroacetate and cancer: new home for an orphan drug?
Biochimica et biophysica acta.
1846(2):617-29
[DOI] 10.1016/j.bbcan.2014.08.005.
[PMID] 25157892.
2014
Intracellular Chloride Concentration and Its Impact On Dichloroacetate Metabolism
The FASEB's Journal.
28(1, S)
2014
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Investigational new drugs.
32(3):452-64
[DOI] 10.1007/s10637-013-0047-4.
[PMID] 24297161.
2014
Sleep disorders associated with primary mitochondrial diseases.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.
10(11):1233-9
[DOI] 10.5664/jcsm.4212.
[PMID] 25325607.
2013
Effects of Vitamin B6 On One-Carbon Metabolism in Oral Contraceptive Users
The FASEB's Journal.
27
2013
Expanding research to provide an evidence base for nutritional interventions for the management of inborn errors of metabolism.
Molecular genetics and metabolism.
109(4):319-28
[DOI] 10.1016/j.ymgme.2013.05.008.
[PMID] 23806236.
2013
Long-term safety of dichloroacetate in congenital lactic acidosis.
Molecular genetics and metabolism.
109(2):139-43
[DOI] 10.1016/j.ymgme.2013.03.019.
[PMID] 23611579.
2013
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
The Journal of nutrition.
143(11):1719-27
[DOI] 10.3945/jn.113.180588.
[PMID] 23966327.
2013
Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects.
PloS one.
8(6)
[DOI] 10.1371/journal.pone.0063544.
[PMID] 23776431.
2013
Pharmacokinetics of oral dichloroacetate in dogs.
Journal of biochemical and molecular toxicology.
27(12):522-5
[DOI] 10.1002/jbt.21518.
[PMID] 24038869.
2013
Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.
Science translational medicine.
5(175)
[DOI] 10.1126/scitranslmed.3004986.
[PMID] 23467562.
2012
Design and implementation of the first randomized controlled trial of coenzyme CoQ₁₀ in children with primary mitochondrial diseases.
Mitochondrion.
12(6):623-9
[DOI] 10.1016/j.mito.2012.09.005.
[PMID] 23022402.
2012
Development of optimized AAV3 serotype vectors: mechanism of high-efficiency transduction of human liver cancer cells.
Gene therapy.
19(4):375-84
[DOI] 10.1038/gt.2011.105.
[PMID] 21776025.
2012
Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.
Journal of clinical pharmacology.
52(6):837-49
[DOI] 10.1177/0091270011405664.
[PMID] 21642471.
2012
Long-Term Safety of Dichloroacetate in Congenital Lactic Acidosis
Mitochondrion.
12(5)
[DOI] 10.1016/j.mito.2012.07.019.
2012
Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women.
The Journal of nutrition.
142(10):1791-7
[PMID] 22955512.
2012
Phase 3 Trial of Coenzyme Q(10) in Children With Mitochondrial Diseases
Mitochondrion.
12(5)
[DOI] 10.1016/j.mito.2012.07.017.
2012
Phenylbutyrate Therapy for Pyruvate Dehydrogenase Complex (Pdhc) Deficiency
Journal of Inherited Metabolic Disease.
35
2012
Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
Drug metabolism and disposition: the biological fate of chemicals.
40(2):232-9
[DOI] 10.1124/dmd.111.041533.
[PMID] 22028318.
2012
Rapid Breath Test for in Vivo Determination of Human Pyruvate Dehydrogenase Complex Activity
Mitochondrion.
12(5)
[DOI] 10.1016/j.mito.2012.07.010.
2012
The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.
Aging cell.
11(3):371-7
[DOI] 10.1111/j.1474-9726.2012.00805.x.
[PMID] 22321732.
2012
The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients.
Molecular genetics and metabolism.
105(1):34-43
[DOI] 10.1016/j.ymgme.2011.09.032.
[PMID] 22079328.
2012
The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients.
Molecular genetics and metabolism.
106(3):385-94
[PMID] 22896851.
2011
Considerations for quantification of lipids in nerve tissue using matrix-assisted laser desorption/ionization mass spectrometric imaging.
Rapid communications in mass spectrometry : RCM.
25(20):3178-84
[DOI] 10.1002/rcm.5189.
[PMID] 21953974.
2011
Dichloroacetate-Dependent Inactivation of Gstz1 in Human Liver Cytosol Is Modulated By Physiologically Important Anions in a Gstz1 Haplotype-Dependent Manner
Drug Metabolism Reviews.
43
2011
Effect of Dichloroacetate in Canine Pulmonary Arterial Hypertension: a Pilot Study
Journal of Veterinary Internal Medicine.
25:762-763
2011
Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts.
Molecular genetics and metabolism.
104(3):255-60
[DOI] 10.1016/j.ymgme.2011.07.023.
[PMID] 21846590.
2011
Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.
The Journal of pharmacology and experimental therapeutics.
336(1):87-94
[DOI] 10.1124/jpet.110.173195.
[PMID] 20884751.
2011
Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women.
The Journal of nutrition.
141(5):835-42
[DOI] 10.3945/jn.110.134197.
[PMID] 21430249.
2011
Predictability of Glutathione Transferase Zeta 1 Haplotype On Kinetics of Dichloroacetate in Human Trials
Drug Metabolism Reviews.
43:181-182
2011
The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine–both or neither?
Environmental health perspectives.
119(2):155-8
[DOI] 10.1289/ehp.1002554.
[PMID] 20920954.
2011
Why are there no proven therapies for genetic mitochondrial diseases?
Mitochondrion.
11(5):679-85
[DOI] 10.1016/j.mito.2011.05.002.
[PMID] 21605707.
2010
Adeno-Associated Virus-Mediated Knockdown of Pyruvate Dehydrogenase E1 Alpha in Specific Regions of the Rat Brain
Mitochondrion.
10
[DOI] 10.1016/j.mito.2009.12.01.
2010
An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α.
Molecular genetics and metabolism.
101(2-3):183-91
[DOI] 10.1016/j.ymgme.2010.07.008.
[PMID] 20685142.
2010
Neurocognitive Correlates of Mitochondrial Dysfunction: a Multiple Case Study
Molecular Genetics and Metabolism.
99:208-209
2009
AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells.
Molecular genetics and metabolism.
98(3):289-99
[DOI] 10.1016/j.ymgme.2009.05.010.
[PMID] 19586787.
2009
High-Efficiency Transduction of Human Hepatoblastoma and Hepatocellular Carcinoma Cells By the Wild-Type and the Tyrosine-Mutant Aav3 Serotype Vectors
Molecular Therapy.
17
2009
Imaging of lipids in spinal cord using intermediate pressure matrix-assisted laser desorption-linear ion trap/Orbitrap MS.
Analytical chemistry.
81(20):8488-95
[DOI] 10.1021/ac901387u.
[PMID] 19751051.
2009
Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women.
The Journal of nutrition.
139(3):452-60
[DOI] 10.3945/jn.108.099184.
[PMID] 19158217.
2009
Peripheral neuropathy in rats exposed to dichloroacetate.
Journal of neuropathology and experimental neurology.
68(9):985-93
[DOI] 10.1097/NEN.0b013e3181b40217.
[PMID] 19680144.
2009
Production of 1-carbon units from glycine is extensive in healthy men and women.
The Journal of nutrition.
139(4):666-71
[DOI] 10.3945/jn.108.103580.
[PMID] 19244382.
2009
Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women.
The American journal of clinical nutrition.
90(2):336-43
[DOI] 10.3945/ajcn.2009.27747.
[PMID] 19515736.
2008
A combined therapeutic approach for pyruvate dehydrogenase deficiency using self-complementary adeno-associated virus serotype-specific vectors and dichloroacetate.
Molecular genetics and metabolism.
93(4):381-7
[DOI] 10.1016/j.ymgme.2007.10.131.
[PMID] 18206410.
2008
Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.
The Journal of pharmacology and experimental therapeutics.
324(3):1163-71
[PMID] 18096758.
2008
Apoptotic Cell Death Is Increased in Fibroblasts From Pyruvate Dehydrogenase Deficient Individuals.
Molecular Genetics and Metabolism.
93
2008
Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate.
Pediatrics.
121(5):e1223-8
[DOI] 10.1542/peds.2007-2062.
[PMID] 18411236.
2008
Pyruvate dehydrogenase complex deficiency caused by ubiquitination and proteasome-mediated degradation of the E1 subunit.
The Journal of biological chemistry.
283(1):237-243
[DOI] 10.1074/jbc.M704748200.
[PMID] 17923481.
2008
Role of dichloroacetate in the treatment of genetic mitochondrial diseases.
Advanced drug delivery reviews.
60(13-14):1478-87
[DOI] 10.1016/j.addr.2008.02.014.
[PMID] 18647626.
2008
The heme precursor delta-aminolevulinate blocks peripheral myelin formation.
Journal of neurochemistry.
106(5):2068-79
[DOI] 10.1111/j.1471-4159.2008.05552.x.
[PMID] 18665889.
2007
Dichloroacetate causes reversible demyelination in vitro: potential mechanism for its neuropathic effect.
Journal of neurochemistry.
100(2):429-36
[PMID] 17241159.
2007
Down-regulation of expression of rat pyruvate dehydrogenase E1alpha gene by self-complementary adeno-associated virus-mediated small interfering RNA delivery.
Mitochondrion.
7(4):253-9
[PMID] 17392036.
2007
Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2]glycine and [(2)H3]leucine.
The Journal of nutrition.
137(12):2647-52
[PMID] 18029478.
2007
MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue.
Analytical chemistry.
79(21):8170-5
[PMID] 17894472.
2006
A GC-MS/MS method for the quantitative analysis of low levels of the tyrosine metabolites maleylacetone, succinylacetone, and the tyrosine metabolism inhibitor dichloroacetate in biological fluids and tissues.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
837(1-2):125-32
[PMID] 16713404.
2006
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.
Pediatrics.
117(5):1519-31
[PMID] 16651305.
2006
Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.
Neurology.
66(3):324-30
[PMID] 16476929.
2006
Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1.
Biochemical pharmacology.
71(11):1648-61
[PMID] 16581029.
2006
Human Kinetics of Orally and Intravenously Administered Low Dose 1,2-13C Dichloroacetate
Clinical Pharmacology & Therapeutics.
46(12):1449-1459
2006
Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate.
Journal of clinical pharmacology.
46(12):1449-59
[PMID] 17101744.
2006
Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.
Drug metabolism and disposition: the biological fate of chemicals.
34(1):36-42
[PMID] 16199472.
2006
Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate.
Molecular genetics and metabolism.
89(1-2):97-105
[PMID] 16765624.
2006
Peripheral neuropathy in genetic mitochondrial diseases.
Pediatric neurology.
34(2):127-31
[PMID] 16458825.
2006
Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women.
The Journal of nutrition.
136(2):373-8
[PMID] 16424114.
2006
Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.
Mitochondrion.
6(3):126-35
[PMID] 16725381.
2005
Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men.
The American journal of clinical nutrition.
81(3):648-55
[PMID] 15755835.
2005
Effects of alginate encapsulation on mitochondrial activity.
Journal of materials science. Materials in medicine.
16(6):521-4
[PMID] 15928867.
2005
Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women.
The Journal of nutrition.
135(5):1045-50
[PMID] 15867279.
2005
Metabolic complications of severe malaria.
Current topics in microbiology and immunology.
295:105-36
[PMID] 16265889.
2005
Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides.
The Journal of nutrition.
135(3):389-96
[PMID] 15735068.
2005
The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women.
The Journal of nutrition.
135(5):1040-4
[PMID] 15867278.
2004
Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism.
The Journal of clinical endocrinology and metabolism.
89(4):1733-8
[PMID] 15070938.
2004
Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets.
The Journal of clinical endocrinology and metabolism.
89(4):1641-5
[PMID] 15070924.
2004
Effects of exercise on emerging and traditional cardiovascular risk factors.
Preventive medicine.
39(5):894-902
[PMID] 15475021.
2004
Liquid chromatography-tandem mass spectrometry method for the simultaneous determination of delta-ALA, tyrosine and creatinine in biological fluids.
Clinica chimica acta; international journal of clinical chemistry.
350(1-2):219-30
[PMID] 15530481.
2004
Methylphenidate does not improve cognitive function in healthy sleep-deprived young adults.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
52(3):192-201
[DOI] 10.1136/jim-52-03-34.
[PMID] 15222409.
2004
Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor.
American journal of physiology. Endocrinology and metabolism.
286(2):E272-9
[PMID] 14559726.
2004
Unified gas chromatographic-mass spectrometric method for quantitating tyrosine metabolites in urine and plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
808(2):153-61
[PMID] 15261808.
2003
A prospective comparison of malaria with other severe diseases in African children: prognosis and optimization of management.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
37(7):890-7
[PMID] 13130399.
2003
Efficacy of dichloroacetate as a lactate-lowering drug.
Journal of clinical pharmacology.
43(7):683-91
[PMID] 12856382.
2003
Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults.
Diabetes care.
26(3):557-62
[PMID] 12610001.
2003
Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.
Biochemical pharmacology.
66(10):2029-38
[PMID] 14599561.
2003
Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.
Journal of clinical pharmacology.
43(4):386-96
[PMID] 12723459.
2003
Simultaneous determination of trace levels of nine haloacetic acids in biological samples as their pentafluorobenzyl derivatives by gas chromatography/tandem mass spectrometry in electron capture negative ion chemical ionization mode.
Analytical chemistry.
75(16):4065-80
[PMID] 14632119.
2003
The pyruvate dehydrogenase complex as a target for gene therapy.
Current gene therapy.
3(3):239-45
[PMID] 12762482.
2002
Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors.
Molecular therapy : the journal of the American Society of Gene Therapy.
6(3):394-9
[PMID] 12231176.
2002
Renal manifestations of congenital lactic acidosis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
39(1):12-23
[PMID] 11774096.
2001
“Bench-to-bedside”–the wrong paradigm for patient-oriented investigation.
Academic medicine : journal of the Association of American Medical Colleges.
76(6)
[PMID] 11401804.
2001
Caveats when considering ketogenic diets for the treatment of pyruvate dehydrogenase complex deficiency.
The Journal of pediatrics.
138(3):390-5
[PMID] 11241048.
2001
Deficiencies of folate and vitamin B(6) exert distinct effects on homocysteine, serine, and methionine kinetics.
American journal of physiology. Endocrinology and metabolism.
281(6):E1182-90
[PMID] 11701432.
2001
Early recognition of acute cardiovascular beriberi by interpretation of hemodynamics.
Journal of clinical anesthesia.
13(3):230-8
[PMID] 11377164.
2001
Population pharmacokinetics of intramuscular quinine in children with severe malaria.
Antimicrobial agents and chemotherapy.
45(6):1803-9
[PMID] 11353629.
2001
QUICKI does not accurately reflect changes in insulin sensitivity with exercise training.
The Journal of clinical endocrinology and metabolism.
86(9):4115-9
[PMID] 11549635.
2001
Teaching hypothesis-oriented thinking to medical students: the University of Florida’s clinical investigation program.
Academic medicine : journal of the Association of American Medical Colleges.
76(3):287-92
[PMID] 11242585.
2000
Glucose and lactate kinetics in children with severe malaria.
The Journal of clinical endocrinology and metabolism.
85(4):1569-76
[PMID] 10770199.
2000
Pharmacokinetics and pharmacodynamic effects of nicotine nasal spray devices on cardiovascular and pulmonary function.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
48(6):435-40
[PMID] 11094866.
2000
Primed, constant infusion with [2H3]serine allows in vivo kinetic measurement of serine turnover, homocysteine remethylation, and transsulfuration processes in human one-carbon metabolism.
The American journal of clinical nutrition.
72(6):1535-41
[PMID] 11101483.
2000
Recombinant adeno-associated virus vector-based gene transfer for defects in oxidative metabolism.
Human gene therapy.
11(15):2067-78
[PMID] 11044909.
1999
Determination of chloral hydrate metabolites in human plasma by gas chromatography-mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
19(3-4):309-18
[PMID] 10704096.
1999
Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity.
Biochemical and biophysical research communications.
262(3):752-6
[PMID] 10471397.
1999
Ischemia induces a selective biphasic response in brain mitochondrial mRNA levels.
Neuroreport.
10(7):1593-8
[PMID] 10380987.
1999
Regulation of brain glucose transporters by glucose and oxygen deprivation.
Metabolism: clinical and experimental.
48(4):422-31
[PMID] 10206432.
1999
The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis.
The Journal of pediatrics.
134(1):99-102
[PMID] 9880457.
1998
Apolipoprotein B metabolism in hypertriglyceridemic diabetic patients administered either a fish oil- or vegetable oil-enriched diet.
Journal of lipid research.
39(2):388-401
[PMID] 9507999.
1998
Clinical pharmacology and toxicology of dichloroacetate.
Environmental health perspectives.
106 Suppl 4(Suppl 4):989-94
[PMID] 9703483.
1998
Effects of dichloroacetate in patients with congestive heart failure.
Clinical cardiology.
21(12):888-92
[PMID] 9853180.
1998
Magnetic resonance spectroscopy: use in monitoring MELAS treatment.
Archives of neurology.
55(6):849-52
[PMID] 9626777.
1998
Metformin and lactic acidosis: guilt by association?
Diabetes care.
21(10):1587-8
[PMID] 9773715.
1998
Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate.
Drug metabolism and disposition: the biological fate of chemicals.
26(11):1134-43
[PMID] 9806957.
1998
Pharmacokinetics, metabolism and toxicology of dichloroacetate.
Drug metabolism reviews.
30(3):499-539
[PMID] 9710704.
1997
Determination of dichloroacetate and its metabolites in human plasma by gas chromatography-mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications.
703(1-2):75-84
[PMID] 9448064.
1997
Dichloroacetate as metabolic therapy for myocardial ischemia and failure.
American heart journal.
134(5 Pt 1):841-55
[PMID] 9398096.
1997
Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats.
Drug metabolism and disposition: the biological fate of chemicals.
25(11):1223-7
[PMID] 9351896.
1997
Kinetics and metabolism of chloral hydrate in children: identification of dichloroacetate as a metabolite.
Biochemical and biophysical research communications.
235(3):695-8
[PMID] 9207222.
1997
Lactic acidosis and other mitochondrial disorders.
Metabolism: clinical and experimental.
46(3):306-21
[PMID] 9054475.
1997
Pharmacokinetics of dichloroacetate in adult patients with lactic acidosis.
Journal of clinical pharmacology.
37(5):416-25
[PMID] 9156374.
1997
The 3H-leucine tracer: its use in kinetic studies of plasma lipoproteins.
Metabolism: clinical and experimental.
46(3):333-42
[PMID] 9054478.
1997
Treatment of congenital lactic acidosis with dichloroacetate.
Archives of disease in childhood.
77(6):535-41
[PMID] 9496194.
1995
Kinetic evidence for both a fast and a slow secretory pathway for apolipoprotein A-I in humans.
Journal of lipid research.
36(7):1618-28
[PMID] 7595084.
1995
Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria.
QJM : monthly journal of the Association of Physicians.
88(5):341-9
[PMID] 7796089.
1995
Plasmodium berghei infection: dichloroacetate improves survival in rats with lactic acidosis.
Experimental parasitology.
80(4):624-32
[PMID] 7758543.
1994
ApoB metabolism in familial hypercholesterolemia. Inconsistencies with the LDL receptor paradigm.
Arteriosclerosis and thrombosis : a journal of vascular biology.
14(4):501-10
[PMID] 8148348.
1994
Natural history and course of acquired lactic acidosis in adults. DCA-Lactic Acidosis Study Group.
The American journal of medicine.
97(1):47-54
[PMID] 8030656.
1994
Nutrition principles for the management of diabetes and related complications.
Diabetes care.
17(5):490-518
[PMID] 8062628.
1993
Lactic acidosis.
Endocrinology and metabolism clinics of North America.
22(2):221-45
[PMID] 8325284.
1993
Lipoprotein-X fails to inhibit hydroxymethylglutaryl coenzyme A reductase in HepG2 cells.
Metabolism: clinical and experimental.
42(7):807-13
[PMID] 8345791.
1992
A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group.
The New England journal of medicine.
327(22):1564-9
[PMID] 1435883.
1992
Fibric acid derivatives: effects on the synthesis of isoprenoid lipids in cultured human lymphocytes.
Biochimica et biophysica acta.
1127(2):168-73
[PMID] 1643103.
1992
Preparation and stability of intravenous solutions of sodium dichloroacetate (DCA).
Journal of parenteral science and technology : a publication of the Parenteral Drug Association.
46(1):16-8
[PMID] 1625103.
1992
Should NIDDM patients be on high-carbohydrate, low-fat diets? Affirmative.
Hospital practice (Office ed.).
27 Suppl 1:6-10; discussion 14
[PMID] 1347544.
1991
Biological effects of omega-3 fatty acids in diabetes mellitus.
Diabetes care.
14(12):1160-79
[PMID] 1773702.
1991
Disposition and pharmacodynamics of dichloroacetate (DCA) and oxalate following oral DCA doses.
Biopharmaceutics & drug disposition.
12(5):375-90
[PMID] 1878534.
1991
Dolichol biosynthesis in human malignant cells.
The Biochemical journal.
278 ( Pt 3)(Pt 3):741-7
[PMID] 1654890.
1991
Haemodialysis studies with dichloroacetate.
European journal of clinical pharmacology.
40(6):613-7
[PMID] 1884744.
1991
In vivo regulation of human leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase: increased enzyme protein concentration and catalytic efficiency in human leukemia and lymphoma.
Journal of lipid research.
32(8):1237-52
[PMID] 1770307.
1991
Metabolic pathways of apolipoprotein B in heterozygous familial hypercholesterolemia: studies with a [3H]leucine tracer.
Journal of lipid research.
32(11):1823-36
[PMID] 1770302.
1991
Nutritional regulation of cholesterol synthesis and apolipoprotein B kinetics: studies in patients with familial hypercholesterolemia and normal subjects treated with a high carbohydrate, low fat diet.
Journal of lipid research.
32(11):1837-48
[PMID] 1770303.
1990
Chronic toxicity of dichloroacetate: possible relation to thiamine deficiency in rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
14(2):327-37
[PMID] 2318357.
1990
Defects in the E2 lipoyl transacetylase and the X-lipoyl containing component of the pyruvate dehydrogenase complex in patients with lactic acidemia.
The Journal of clinical investigation.
85(6):1821-4
[PMID] 2112155.
1989
Dose-response effects of dietary marine oil on carbohydrate and lipid metabolism in normal subjects and patients with hypertriglyceridemia.
Metabolism: clinical and experimental.
38(10):946-56
[PMID] 2677610.
1989
Pathogenesis and treatment of lipoprotein disorders.
Comprehensive therapy.
15(4):28-44
[PMID] 2650981.
1989
The pharmacology of dichloroacetate.
Metabolism: clinical and experimental.
38(11):1124-44
[PMID] 2554095.
1988
Developmental pattern of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the rat.
Life sciences.
42(8):943-7
[PMID] 3343892.
1988
Dichloroacetate in the treatment of lactic acidosis.
Annals of internal medicine.
108(1):58-63
[PMID] 3337517.
1988
Erythrocyte contamination of leukocyte populations following density-gradient centrifugation results in artificially high levels of human leukocyte HMG-CoA reductase activity.
Lipids.
23(12):1154-8
[PMID] 3226231.
1988
Lipodystrophic diabetes mellitus. Investigations of lipoprotein metabolism and the effects of omega-3 fatty acid administration in two patients.
Metabolism: clinical and experimental.
37(10):944-51
[PMID] 3050365.
1988
Myocardial metabolic and hemodynamic effects of dichloroacetate in coronary artery disease.
The American journal of cardiology.
61(1):65-70
[PMID] 3337018.
1987
Advances in the treatment of coronary heart disease: fish oils, cholestyramine, and mevinolin.
Cardiovascular clinics.
18(1):267-79
[PMID] 3300984.
1987
Development of a noncompetitive, solid phase, bridged biotin-avidin enzyme immunoassay for measurement of human leukocyte microsomal HMG-CoA reductase protein concentration.
Journal of lipid research.
28(3):292-304
[PMID] 3553404.
1987
Dichloroacetate derivatives. Metabolic effects and pharmacodynamics in normal rats.
Life sciences.
41(18):2167-76
[PMID] 3669916.
1987
In vivo regulation of human mononuclear leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase. Decreased enzyme catalytic efficiency in familial hypercholesterolemia.
The Journal of clinical investigation.
80(5):1401-8
[PMID] 2824560.
1987
In vivo regulation of human mononuclear leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase. Studies in normal subjects.
The Journal of clinical investigation.
79(4):1125-32
[PMID] 3558818.
1986
Inhibition of human leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by ascorbic acid. An effect mediated by the free radical monodehydroascorbate.
The Journal of biological chemistry.
261(16):7127-35
[PMID] 3711081.
1986
Lactic acidosis: the case against bicarbonate therapy.
Annals of internal medicine.
105(2):276-9
[PMID] 3014943.
1985
Ascorbic acid regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in guinea pig liver.
Biochimica et biophysica acta.
834(1):134-8
[PMID] 4038887.
1985
Plasma concentrations and metabolic effects of intravenous sodium dichloroacetate.
Clinical pharmacology and therapeutics.
37(1):89-93
[PMID] 3965240.
1984
Measurement of human leukocyte microsomal HMG-CoA reductase activity.
Journal of lipid research.
25(9):967-78
[PMID] 6491541.
1984
Regulation of human leukocyte microsomal hydroxymethylglutaryl-CoA reductase activity by a phosphorylation and dephosphorylation mechanism.
Biochimica et biophysica acta.
805(3):245-51
[PMID] 6487662.
1983
Dietary carbohydrate decreases 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in rat liver.
Biochemical and biophysical research communications.
113(3):888-94
[PMID] 6870899.
1983
Hyperlipoproteinemias: pathogenesis, diagnosis, and treatment.
Comprehensive therapy.
9(3):27-39
[PMID] 6839688.
1983
Primary empty sella, hyperprolactinemia, and isolated ACTH deficiency after postpartum hemorrhage.
The American journal of medicine.
74(5):905-8
[PMID] 6301277.
1983
Regulation of rat liver hydroxymethylglutaryl coenzyme A reductase by a new class of noncompetitive inhibitors. Effects of dichloroacetate and related carboxylic acids on enzyme activity.
The Journal of clinical investigation.
72(5):1575-85
[PMID] 6630519.
1983
Somatostatinoma syndrome: does a clinical entity exist?
Acta endocrinologica.
102(1):80-7
[PMID] 6297217.
1983
Treatment of lactic acidosis with dichloroacetate.
The New England journal of medicine.
309(7):390-6
[PMID] 6877297.
1982
Cholesterol reduction by a high-glucose diet in a patient with homozygous familial hypercholesterolemia. A preliminary report.
The American journal of medicine.
72(6):889-93
[PMID] 7091159.
1982
Combination H1 and H2 receptor antagonist therapy in diabetic autonomic neuropathy.
Southern medical journal.
75(5):634-5
[PMID] 6123154.
1982
Isolated ACTH deficiency: a heterogeneous disorder. Critical review and report of four new cases.
Medicine.
61(1):13-24
[PMID] 6276646.
1982
Morphologic abnormalities of erythrocytes from patients with homozygous familial hypercholesterolemia.
Biochimica et biophysica acta.
712(1):211-6
[PMID] 7115746.
1982
Prolonged hypolactatemia and increased total pyruvate dehydrogenase activity by dichloroacetate.
Biochemical pharmacology.
31(7):1295-300
[PMID] 7092922.
1982
Stimulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by o,p’-DDD.
Biochemical pharmacology.
31(5):857-60
[PMID] 7082353.
1981
A familial glucagonoma syndrome: genetic, clinical and biochemical features.
The American journal of medicine.
70(5):1017-26
[PMID] 6112877.
1981
Elevated cholesterol and bile acid synthesis in an adult patient with homozygous familial hypercholesterolemia. Reduction by a high glucose diet.
The Journal of clinical investigation.
68(5):1166-71
[PMID] 7298845.
1981
Lactic acidosis associated with metastatic osteogenic sarcoma.
Southern medical journal.
74(7):868-70
[PMID] 6942511.
1981
The glucagonoma syndrome: clinical features, diagnosis, and treatment.
Endocrine reviews.
2(3):347-61
[PMID] 6268399.
1980
Brief treatment with dichloroacetate does not modify suspected subacute necrotizing encephalomyelitis.
Annals of neurology.
8(6):647-8
[PMID] 7212661.
1980
Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans.
Diabetologia.
19(2):109-13
[PMID] 7418965.
1979
Reduction of serum cholesterol in two patients with homozygous familial hypercholesterolemia by dichloroacetate.
Atherosclerosis.
33(3):285-93
[PMID] 486225.
1979
Toxicity of chronic dichloroacetate.
The New England journal of medicine.
300(7)
[PMID] 215910.
1978
Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia.
The New England journal of medicine.
298(10):526-30
[PMID] 625308.
1977
Effect of dichloroacetate on gluconeogenesis in isolated rat hepatocytes.
Metabolism: clinical and experimental.
26(2):107-16
[PMID] 834145.
1977
Pangamic acid (‘vitamin B15’). A review.
World review of nutrition and dietetics.
27:145-63
[PMID] 333789.
1975
Role of vitamin C in infectious disease and allergic reactions.
Medical hypotheses.
1(2):43-5
[PMID] 1105096.
1974
Treatment of streptozotocin diabetes with di-isopropylammonium dichloroacetate (DIPA).
Diabetes.
23(3):179-82
[PMID] 4274024.
1971
Diisopropylammonium dichloroaccetate: regulation of metabolic intermediates in muscle of alloxan diabetic rats.
Metabolism: clinical and experimental.
20(9):830-4
[PMID] 4254777.
1971
Diisopropylammonium dichloroacetate (DIPA): reversible antagonism towards smooth muscle stimulants and inhibition of acetylcholinesterase in the isolated guinea pig ileum.
Research communications in chemical pathology and pharmacology.
2(4):439-46
[PMID] 5139065.
1970
Diisopropylammonium dichloroacetate (DIPA) and sodium dichloracetate (DCA): effect on glucose and fat metabolism in normal and diabetic tissue.
Metabolism: clinical and experimental.
19(1):71-8
[PMID] 4244198.
1969
Effects of diisopropylammonium dichloroacetate on glucose metabolism.
Proceedings of the Western Pharmacology Society.
12:111-3
[PMID] 5812282.
1969
Review of the pharmacologic and therapeutic effects of diisopropylammonium dichloroacetate (DIPA).
The Journal of clinical pharmacology and the journal of new drugs.
9(5):282-91
[PMID] 4902026.
Grants
Sep 2021
ACTIVE
Phase IIA Trial of Dichloroacetate for Glioblastoma Multiforme, IND137007, 09172019
Role: Principal Investigator
Funding: US FOOD AND DRUG ADMN
Mar 2021
ACTIVE
Activating Pyruvate Dehydrogenase Complex to Improve Barth Syndrome Cardiac Function
Role: Principal Investigator
Funding: WAKE FOREST UNIV
via BARTH SYNDROME FOU
Jul 2020
ACTIVE
Personalized dosing of dichloroacetate for the treatment of rare and common diseases
Role: Principal Investigator
Funding: MEDOSOME BIOTEC
via NATL INST OF HLTH NICHD
Apr 2020
– Mar 2022
DCA Kinetics Analysis
Role: Principal Investigator
Funding: WAKE FOREST UNIV
Sep 2019
– Aug 2023
The North American Mitochondrial Disease Consortium (NAMDC)
Role: Principal Investigator
Funding: COLUMBIA UNIVERSITY
via NATL INST OF HLTH NINDS
Jul 2017
– Jul 2020
Personalized dosing of dichloroacetate for the treatment of rare and common diseases
Role: Principal Investigator
Funding: MEDOSOME BIOTEC
via NATL INST OF HLTH NICHD
Apr 2017
– Mar 2020
Therapeutic use of dichloroacetate in treatment of perinatal mitochondrial deficiency and cardiac dysfunction
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Dec 2016
– Nov 2022
Effects of maternal cortisol on perinatal cardiac metabolism and function
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Sep 2016
– Jun 2017
Personalized Dosing of Dichloroacetate for the Treatment of Rare and Common Diseases
Role: Principal Investigator
Funding: MEDOSOME BIOTEC
via NATL INST OF HLTH NICHD
Sep 2016
– Aug 2021
Developmental Pharmacology of Mitochondrial and Cytosolic GSTZ1
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Jun 2016
ACTIVE
Phase 3 Trial of DCA in PDC Deficiency IND 028,625 (02/04/2015)
Role: Principal Investigator
Funding: US FOOD AND DRUG ADMN
May 2016
– Aug 2023
Miscellaneous Donors
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Sep 2015
– Mar 2016
RAPID HAPLOTYPING PROCEDURE FOR DETERMINING THE RESPONSE OFPATIENTS TO DCA
Role: Principal Investigator
Funding: MEDOSOME BIOTEC
via US FOOD AND DRUG ADMN
Sep 2015
– Sep 2019
NAMDC: Overall Research Plan
Role: Principal Investigator
Funding: COLUMBIA UNIVERSITY
via NATL INST OF HLTH NINDS
Aug 2015
– Jul 2016
Validation of an Observer Reported Outcome (ObsRO) Measure of Home Functionality in Children with Pyruvate Dehydrogenase Complex Deficiency (PDCD)
Role: Principal Investigator
Funding: UNITED MITOCHONDRIAL DISEASE FOU
Apr 2015
– Jun 2021
Clinical and Translational Science Institute (CTSI)
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Sep 2012
– Aug 2016
Developmental Pharmacology of Cytosolic and Mitochondrials GSTZ1-1/MAAI
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
May 2012
ACTIVE
Revenue for Project Open Label DCA Admin
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Education
Fellowship – Endocrinology, Diabetes and Metabolism
1980
·
Vanderbilt University
Residency – Internal Medicine
1978
·
Vanderbilt University
Internship – Internal Medicine
1977
·
Vanderbilt University
Medical Degree
1976
·
Vanderbilt University
PhD – Pharmacology
1971
·
University of California, San Francisco
Contact Details
Phones:
- Business:
- (352) 273-8655
Emails:
- Business:
- pws@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100226
GAINESVILLE FL 32610 - Business Street:
-
N1-18 MSB
GAINESVILLE FL 326100001