Human adrenal tumors are difficult to study, in part, due to the absence of cultured cell lines that faithfully represent adrenal cells in the early stages of transformation. To fill this void, we have developed two novel Human Adrenocortical Adenoma (HAA) cell lines (HAA1 & HAA2). These HAA1/2 cell lines are unique in their ability to exit a non-functional state and undergo differentiation. Specifically, our group is interested in studying ways to help induce expression steroidogenic enzymes upon treatment with histone deacetylase (HDAC) inhibitors. With further studies, we are working on finding new factors that can regulate steroidogenic expression in adrenal tumors.
Dr. Barb in front of her poster entitled:
Plasma IGF21 Correlates with Insulin Resistance and Severity Nonalcoholic Steatohepatitis (NASH
She presented at Obesity Week 2017 in Washington DC where she had the honor of being chosen to be highlighted as part of the Poster Tour!
Congratulations Dr. Diana Barb for a wonderful job!